Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome
نویسندگان
چکیده
BackgroundTourette syndrome is characterized by chronic motor and vocal tics. There preliminary evidence of benefit from cannabis products containing Δ9-tetrahydrocannabinol (THC) that coadministration cannabidiol (CBD) improves the side-effect profile safety.MethodsIn this double-blind, crossover trial, participants with severe Tourette were randomly assigned to a 6-week treatment period escalating doses an oral oil 5 mg/ml THC CBD, followed course placebo, or vice versa, separated 4-week washout period. The primary outcome was total tic score on Yale Global Tic Severity Scale (YGTSS; range, 0 50 [higher scores indicate greater severity symptoms]). Secondary outcomes included video-based assessment tics, global impairment, anxiety, depression, obsessive-compulsive symptoms. Outcomes correlated plasma levels cannabinoid metabolites. A computerized cognitive battery administered at beginning end each period.ResultsOverall, 22 (eight female participants) enrolled. Reduction in (at week 6 relative baseline) as measured YGTSS 8.9 (±7.6) active group 2.5 (±8.5) placebo group. In linear mixed-effects model, there significant interaction (active/placebo) visit number (coefficient = −2.28; 95% confidence interval, −3.96 −0.60; P=0.008), indicating decrease (improvement) tics under treatment. correlation between 11-carboxy-tetrahydrocannabinol outcome, which attenuated after exclusion outlier. most common adverse effect headache (n=7); period, it difficulties, including slowed mentation, memory lapses, poor concentration (n=8).ConclusionsIn syndrome, CBD reduced may reduce impairment due disorder; although some associated concentration. (Funded Wesley Medical Research Institute, Brisbane, Lambert Initiative for Cannabinoid Therapeutics, philanthropically-funded research organization University Sydney, Australia; Australian New Zealand Clinical Trials Registry number, ACTRN12618000545268.)
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ژورنال
عنوان ژورنال: NEJM evidence
سال: 2023
ISSN: ['2766-5526']
DOI: https://doi.org/10.1056/evidoa2300012